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The clinical trial compared trazodone versus zolpidem (Ambien), a short-acting nonbenzodiazepine hypnotic, in the treatment of primary insomnia in nondepressed patients.During the first week, both trazodone and zolpidem were similar in improving sleep latency, total sleep time and sleep quality, and decreasing wakefulness after sleep onset.However, at week 2 zolpidem shortened time to fall asleep greater than trazodone.

Comparative efficacy Trazodone versus Zolpidem (Ambien®) Only one high quality comparative study with trazodone has been performed.The diagnosis of RLS is based on a patient’s symptoms and answers to questions concerning family history of similar symptoms, medication use, the presence of other symptoms or medical conditions, or problems with daytime sleepiness. In people with mild to moderate restless legs syndrome, lifestyle changes, such as beginning a regular exercise program, establishing regular sleep patterns, and eliminating or decreasing the use of caffeine, alcohol, and tobacco, may be helpful.Treatment of an RLS-associated condition also may provide relief of symptoms.Trazodone: "off-label" sleeping pill Trazodone hcl is a sedating antidepressant with significant anxiolytic and sedative activity.In practice it is widely used off-label to treat insomnia.

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